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Table 3 Methadone-induced tolerance in male offspring

From: Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring

   ED 50 (mg/kg)  
Prenatal treated Before-CPP After-chronic treatment Degree of tolerance (after-chronic/before-CPP)
Control 1.77 ± 0.13 2.46 ± 0.13** 1.34
Methadone 1.77 ± 0.13 3.08 ± 0.13*** 1.74
Methadone + DM 1.78 ± 0.13 3.28 ± 0.18*** 1.84
DM 1.58 ± 0.18 2.46 ± 0.13* 1.56
  1. Tail-flick test and up-down method were used to determine the ED50. Data are presented as mean ± S.E.M. (n ≥ 6). Two-way ANOVA and Bonferroni post-tests were used to analyze the data. *P < 0.05, **p < 0.01, and ***p < 0.001, compared to the data before CPP of its own group.