Fig. 5
Effects of the large-conductance Ca2+-activated K+ channel blockers on 5-HT-induced coronary responses in L-NAME-treated hearts. a 5-HT-induced coronary flow increases were not significantly affected by penitrem A 1 μM. b Treatment of paxilline 2 μM did not significantly alter 5-HT-induced coronary flow increases. c 5-HT-induced coronary flow increases were significantly suppressed by treatment with TEA 300 μM. Data were expressed as the mean ± SD. #P < 0.05, ##P < 0.01, ###P < 0.005 compared to the treatment (one-ways ANOVA followed by Bonferroni post-test). ƗƗƗP < 0.005 compared to control group; &&&P < 0.005 between the compared groups (2-ways ANOVA followed by Bonferroni post-test)