Fig. 1
From: Structural basis of blocking integrin activation and deactivation for anti-inflammation
Different integrin conformations. a Bent conformation containing the closed headpiece (with low-affinity I domain). b Extended conformation containing the closed headpiece (with intermediate-affinity I-domain). c Extended conformation containing the open headpiece (with the high-affinity I domain). I-EGF, integrin-epidermal growth factor; PSI, plexin/semaphorin/integrin; TM, transmembrane