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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo

Fig. 1

Chemical structure of NEO212. Shown is the carbamate linkage between the monoterpene perillyl alcohol (POH) and the amide functional group of the imidazotetrazine TMZ. Shaded area: TMZ moiety that forms the highly reactive methyldiazonium ion that methylates DNA after spontaneous decomposition of the pro-drug TMZ that takes place in aqueous solution at neutral pH [31]

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