Fig. 1From: Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivoChemical structure of NEO212. Shown is the carbamate linkage between the monoterpene perillyl alcohol (POH) and the amide functional group of the imidazotetrazine TMZ. Shaded area: TMZ moiety that forms the highly reactive methyldiazonium ion that methylates DNA after spontaneous decomposition of the pro-drug TMZ that takes place in aqueous solution at neutral pH [31]Back to article page