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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex

Fig. 3

The sEH inhibitor, AUDA, increases postsynaptic efficiency of I-O glutamatergic transmission but not presynaptic glutamate release in PFC slice. a The I-O relationship was measured by the stimulation intensity and amplitude of fEPSP in the different concentration of 1 μM, 5 μM or 10 μM AUDA. b Mean value of I-O curves of glutamatergic transmission in PFC slices. c Sample traces were an average of 5-10 successive responses. The paired-pulse fEPSPs were evoked with intervals of 30 ms and 90 ms. Calibration; 50 pA, 30 ms. d Paired-pulse ratio was evoked at 30 ms, 60 ms, 90 ms, 120 ms, 150 ms intervals in the different concentration of AUDA. **p < 0.01, ***p < 0.001 vs. vehicle control

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