Fig. 5
From: Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish
The MEK inhibitor, U0126, inhibited skin tumor formation in Tg(krt14: MEK2S219D-GFP) embryos. Tg(Ka14:GFP) embryos were observed by treated with 50 μM U0126 at 2 dpf (a) and 6 dpf (b). Tg(krt14: MEK2S219D-GFP) embryos were observed by treated with 50 μM U0126 at 2 dpf (c) and 6 dpf (d) or treated with DMSO at 6 dpf (e). The white arrow indicated skin papilloma. f The frequency of tumor formation in Tg(krt14: MEK2S219D-GFP) embryos incubated with DMSO (Control) or U0126