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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer

Fig. 4

ZnPP reduced tumor hypoxia-mediated VEGF release. a HCT-15 cells were treated with hemin or ZnPP cultured in normoxia, and the cultured mediums were collected and investigated using ELISA assay. We found that ZnPP (10 μM) decreased VEGF secretion in HCT-15 cells, but hemin did not. b HCT-15 cells was treated with ZnPP and cultured in hypoxia condition. Tumor hypoxia increased VEGF, but ZnPP reduced hypoxia-induced VEGF levels. *p < 0.05. **p < 0.01

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Journal of Biomedical Science

ISSN: 1423-0127