Fig. 6From: Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancerZnPP inhibited tumor growth in the HCt-15-induced tumor xenografts as a potential therapeutic agent. a The mice were treated with PBS, 10 μg or 100 μg of ZnPP three times (day 11, 13, and 16), and the tumor sizes were recorded and compared. We found that 100 μg of ZnPP significantly reduced the tumor growth, and b decreased tumor volume by ~50 %. *p <0.05. **p <0.01Back to article page