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Fig. 10 | Journal of Biomedical Science

Fig. 10

From: Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells

Fig. 10

A model for the BetA effect on TGF-β partitioning between lipid rafts/caveolae- and clathrin-mediated endocytosis. Two major TβR-I-TβR-II complexes (Complexes I and II) are present on the cell surface. Complexes I and II are localized mainly in the non-lipid raft and lipid raft/caveolae microdomains, respectively, of the plasma membrane. BetA treatment results in decreased formation, or the disruption of the lipid raft, and subsequently moves TβR-I-TβR-II to non-lipid raft microdomains where TGF-β binding to the receptors induces Smad2 signaling, leading to cellular responses

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Journal of Biomedical Science

ISSN: 1423-0127