From: Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility
Risk factor | Multivariate aORa | 95Â % CIa |
---|---|---|
Male lung cancer patients | ||
FA gene | ||
  FANCC(rs356665) | ||
   AA vs. AG,GG | 2.06 | 1.13–3.72 |
  FANCD1(rs9634672) |  |  |
   TT vs. GT,GG | 2.24 | 1.31–3.85 |
  FANCL(rs12470316) |  |  |
   TT vs. CT, CC | 1.78 | 1.02–3.13 |
Cigarette smoking | Â | Â |
   Yes vs. No | 2.29 | 1.80–4.46 |
Passive smoking | Â | Â |
   Yes vs. No | 2.83 | 1.79–4.46 |
Female lung cancer patients | Â | Â |
FA gene | Â | Â |
  FANCC(rs4744451) |  |  |
   GG vs. GT,TT | 1.67 | 1.01–2.75 |
  FANCD1(rs9534275) |  |  |
   AA vs. AC,CC | 1.62 | 1.20–2.32 |
  FANCJ/BRIP1/BACH1(rs16945628) |  |  |
   CC vs. CT, TT | 1.44 | 1.02–2.01 |
Passive smoking | Â | Â |
   Yes vs. No | 2.14 | 1.50–3.03 |