Fig. 3

Deficiency of the urokinase-type plasminogen activator (uPA) exacerbated the severity of renal histopathological changes in a focal segmental glomerulosclerosis (FSGS) mouse model. At the end of the experiment, kidney samples were collected for a histopathological examination. a Representative sections from renal tissue in wild-type (WT) and uPA^−/− groups were evaluated with PAS staining (lines 1 and 2), colloidal iron staining (lines 3 and 4), and TUNEL staining (lines 5 and 6), at an original magnification of 400x. Semi-quantification analyses of PAS (b), colloidal iron (c), and TUNEL (d) staining are also presented. ^# p < 0.05 vs. week 0 (W0); *p < 0.05 vs. the WT