Fig. 1
Depletion of Top3α in mitochondria shortens the lifespan of Drosophila. The lifespans of WT (wildtype), rescued, and M1L (a) male, (b) female, and (c) mixed populations were measured. Median lifespan (d), maximum lifespan (e), and 35-day survival rate (f) are shown for each group. d) also shows the log-rank test demonstrating the statistically significant difference in life span between mutant and control flies (❖for P < 10-12 with log-rank test). The total number of flies was 200 for both male and female groups, and 400 for the mixed group