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Table 2 Immunocytochemistry profile of TOP2A and Ki-67 antibodies related to cytopathology classification of cervical smears

From: Immunocytochemical study of TOP2A and Ki-67 in cervical smears from women under routine gynecological care

Cytopathology N HPV+ (%) Immunocytochemistry
TOP2A+ (%) Ki-67+ (%) TOP2A+/Ki-67+ (%) ICC+ (%)
Positive 32*,**,***,**** 28 (87.5) 23* (71.9) 26** (81.2) 19*** (59.4) 30**** (93.7)
 ASC-US 5 3 (60) 2 (40) 3 (60) 1 (20) 4 (80)
  LSIL 19 18 (94.7) 13 (68) 16 (84) 11 (57.9) 18 (94.7)
  HSIL 8 7 (87.5) 8 (100) 7 (87.5) 7 (87.5) 8 (100)
NILM 78 55 (70.5) 28 (36) 21 (27) 18 (23) 31 (39.7)
Total 110 83 51 47 37 61
  1. *p < 0.0007 (OR = 4.563; 95 % CI: 1.857–11.21); **p < 0.0001 (OR = 11.76; 95 % CI: 4.245–32.59); ***p < 0.0007 (OR = 4.872; 95 % CI: 2.019–11.75); ****p < 0.0001 (OR = 22.74; 95 % CI 5.065–102.1)