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Table 6 Comparison of autoimmune profiles before, during, and after vaccination

From: A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment

Patient Antinuclear antibody Rheumatoid factor Thyroglobulin antibody
Day 0 (before) Day 36 (during) Day 57 (after) Day 0 (before) Day 36 (during) Day 57 (after) Day 0 (before) Day 36 (during) Day 57 (after)
1 1:40 1:40 1:40 <20 <20 <20 1:40 1:40 1:40
2 1:40 offa off <20 off off 1.7 off off
3 1:40 1:40 1:40 <20 <20 <20 1:40 6.21 1:40
4 1:40 1:80 off <20 <20 off 1:40 1:40 off
5 (−) (−) (−)b <20 22.9 23.3 1:80 1:80 <1:10
6 (−) (−) (−) <20 <20 <20 1:80 <1:10 <1:10
7 (−) (−) (−) <20 <20 <20 1:40 1:80 1:40
8 (−) (−) off <20 <20 off 1:80 1:40 off
9 (−) (−) (−) 60.6 59.5 44.2 1:160 1:80 <1:10
10 1:640 1:>1280 1:>1280 <20 20.5 21.4 1:40 <1:10 1:40
11 1:40 1:40 1:40 <20 <20 <20 5.11 3.09 7.81
12 1:40 1:40 1:40 <20 <20 <20 14.2 0.71 1.14
  1. “off” indicates samples were not available for analysis due to withdraw or termination of enrolled patients from this study
  2. a“off” indicates samples not available for analysis because of withdrawal or termination of enrolled patients from this study
  3. b(−): not detected