Fig. 3
From: Loss of porin function in dopaminergic neurons of Drosophila is suppressed by Buffy
Loss of porin function enhances the α-synuclein-induced reduction in lifespan and age-dependent loss of climbing ability. a The directed inhibition of porin along with α-synuclein expression in the neurons decreased lifespan with a median survival of 50 and 56 days when compared to 60 days for the control flies that express α-synuclein along with the lacZ transgene. Genotypes are UAS-α-synuclein; Ddc-Gal4/ UAS-lacZ, UAS-α-synuclein; Ddc-Gal4/UAS-porin-RNAi (1) and UAS-α-synuclein; Ddc-Gal4/ UAS-porin-RNAi (2). Longevity is shown as percent survival (P < 0.05, determined by log-rank (Mantel-Cox) test with n ≤ 200). b The co-expression of porin-RNAi with α-synuclein resulted in reduction of climbing ability over time when compared to the controls. The genotypes are UAS-α-synuclein; Ddc-Gal4/UAS-lacZ, UAS-α-synuclein; Ddc-Gal4/UAS-porin-RNAi (1) and UAS-α-synuclein; Ddc-Gal4/UAS-porin-RNAi (2). Analysis was done by nonlinear fitting of the climbing curves and significance was determined by comparing the 95% CI. Error bars indicate SEM and n = 50