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Table 3 Established and putative homologs of NCL proteins in other model organisms

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Human Protein S. cerevisiae (budding yeast)
S. pombe (fission yeast) 		C. elegans (nematode) D. melanogaster (fruit fly) D. rerio (zebrafish)
PPT1/CLN1
Accession: NP_000301 		Yes (S. pombe) [26–28] Yes [26] Yes [26–28] Yes [27, 28]
TPP1/CLN2
Accession: NP_000382 		No No No Yes [27, 28]
CLN3
Accession: NP_000077 		Yes [26–28] Yes [26–28] Yes [26–28] Yes [27, 28]
DNAJC5/CLN4
Accession: NP_079495 		Yes [a] Yes [28] Yes [c] Yes [27, 28]
CLN5
Accession: NP_006484 		No No No Yes [27, 28]
CLN6
Accession: NP_060352 		No No No Yes [27, 28]
MFSD8/CLN7
Accession: NP_689991 		No Yes [b] Yes [27, 28] Yes [27, 28]
CLN8
Accession: NP_061764 		No No No Yes [27, 28]
CTSD/CLN10
Accession: NP_001900 		Yes [26–28] Yes [26, 28] Yes [26–28] Yes [27, 28]
PGRN/CLN11
Accession: NP_002078 		No Yes [b] No Yes [27, 28]
ATP13A2/CLN12
Accession: NP_071372 		Yes [28],[a] Yes [b] Yes [c] Yes [27, 28]
CTSF/CLN13
Accession: NP_003784 		No Yes [b] Yes [c] Yes [27, 28]
KCTD7/CLN14
Accession: NP_694578 		No Yes [b] Yes [c] Yes [27, 28]
  1. The information contained within this table is described in detail elsewhere [26–28]. The presence and absence of homologs in each organism was confirmed with NCBI BLASTp [a], WormBase BLASTp [b], and FlyBase BLASTp [c]
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Journal of Biomedical Science

ISSN: 1423-0127