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Table 3 Established and putative homologs of NCL proteins in other model organisms

From: Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Human Protein S. cerevisiae (budding yeast)
S. pombe (fission yeast)
C. elegans (nematode) D. melanogaster (fruit fly) D. rerio (zebrafish)
PPT1/CLN1
Accession: NP_000301
Yes (S. pombe) [2628] Yes [26] Yes [2628] Yes [27, 28]
TPP1/CLN2
Accession: NP_000382
No No No Yes [27, 28]
CLN3
Accession: NP_000077
Yes [2628] Yes [2628] Yes [2628] Yes [27, 28]
DNAJC5/CLN4
Accession: NP_079495
Yes [a] Yes [28] Yes [c] Yes [27, 28]
CLN5
Accession: NP_006484
No No No Yes [27, 28]
CLN6
Accession: NP_060352
No No No Yes [27, 28]
MFSD8/CLN7
Accession: NP_689991
No Yes [b] Yes [27, 28] Yes [27, 28]
CLN8
Accession: NP_061764
No No No Yes [27, 28]
CTSD/CLN10
Accession: NP_001900
Yes [2628] Yes [26, 28] Yes [2628] Yes [27, 28]
PGRN/CLN11
Accession: NP_002078
No Yes [b] No Yes [27, 28]
ATP13A2/CLN12
Accession: NP_071372
Yes [28],[a] Yes [b] Yes [c] Yes [27, 28]
CTSF/CLN13
Accession: NP_003784
No Yes [b] Yes [c] Yes [27, 28]
KCTD7/CLN14
Accession: NP_694578
No Yes [b] Yes [c] Yes [27, 28]
  1. The information contained within this table is described in detail elsewhere [2628]. The presence and absence of homologs in each organism was confirmed with NCBI BLASTp [a], WormBase BLASTp [b], and FlyBase BLASTp [c]