Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis

Table 3 Established and putative homologs of NCL proteins in other model organisms

Human Protein	S. cerevisiae (budding yeast) S. pombe (fission yeast)	C. elegans (nematode)	D. melanogaster (fruit fly)	D. rerio (zebrafish)
PPT1/CLN1 Accession: NP_000301	Yes (S. pombe) [26–28]	Yes [26]	Yes [26–28]	Yes [27, 28]
TPP1/CLN2 Accession: NP_000382	No	No	No	Yes [27, 28]
CLN3 Accession: NP_000077	Yes [26–28]	Yes [26–28]	Yes [26–28]	Yes [27, 28]
DNAJC5/CLN4 Accession: NP_079495	Yes [a]	Yes [28]	Yes [c]	Yes [27, 28]
CLN5 Accession: NP_006484	No	No	No	Yes [27, 28]
CLN6 Accession: NP_060352	No	No	No	Yes [27, 28]
MFSD8/CLN7 Accession: NP_689991	No	Yes [b]	Yes [27, 28]	Yes [27, 28]
CLN8 Accession: NP_061764	No	No	No	Yes [27, 28]
CTSD/CLN10 Accession: NP_001900	Yes [26–28]	Yes [26, 28]	Yes [26–28]	Yes [27, 28]
PGRN/CLN11 Accession: NP_002078	No	Yes [b]	No	Yes [27, 28]
ATP13A2/CLN12 Accession: NP_071372	Yes [28],[a]	Yes [b]	Yes [c]	Yes [27, 28]
CTSF/CLN13 Accession: NP_003784	No	Yes [b]	Yes [c]	Yes [27, 28]
KCTD7/CLN14 Accession: NP_694578	No	Yes [b]	Yes [c]	Yes [27, 28]

The information contained within this table is described in detail elsewhere [26–28]. The presence and absence of homologs in each organism was confirmed with NCBI BLASTp [a], WormBase BLASTp [b], and FlyBase BLASTp [c]

ISSN: 1423-0127