Fig. 1

Effects of Kv7 channel modulators on blood pressure in normal rats. a. Intravenous injection of increasing doses of linopridine (0.1-6 mg/kg in 0.5 mL normal saline). Arrows indicate time points of drug injection. Open squares: Systolic blood pressure. Grey squares: Diastolic blood pressure. Black Squares: Mean arterial blood pressure. BP: Blood pressure (mmHg). N = 3. Data are mean ± SD. b. Intravenous injection of increasing doses of retigabine (0.1-12 mg/kg in 0.5 mL normal saline) followed by an intravenous injection of 6 mg/kg linopirdine in 0.5 mL normal saline. Open squares: Systolic blood pressure. Grey squares: Diastolic blood pressure. Black Squares: Mean arterial blood pressure. BP: Blood pressure (mmHg). N = 3