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Table 1 General characteristics of monocytes/macrophages subsets participating in post-infarction cardiac remodeling

From: Macrophage activation and polarization in post-infarction cardiac remodeling

M1 inflammatory monocytes/macrophages (classically activated macrophages) M2 monocytes/macrophages (alternatively activated macrophages)
Markers
 Ly6Chi
 CC chemokine receptor CCR2
Ly6Clow
Fractalkine receptor CX3CR1
MHCIIlow
MHCIIhiCD11clowCCR2-
MHCIIhiCD11chiCCR2hi
CD206+F4/80+CD11b+ M2-
Mediators of activation
 Cardiac fibroblasts
 IFN-γ
 Granulocyte-macrophage colony-stimulating factor
Cardiac fibroblasts
Hydrogen sulfide
IL-1α
Macrophage-derived urokinase plasminogen activator
Osteopontin
Secreted cytokines
 IL-1β
 IL-6
 TNF-α
VEGF
TGF-ß
Contributions to cardiac injury and repair
 Mediating of inflammatory phase
 Proteolysis
 Phagocytosis of cell debris
Resolution of inflammation
Myofibroblast activation
Neoangiogenesis