Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

Table 4 Predicted group I C19MC-AAGUGC-miRNA target genes associated with cell survival pathways

Gene Symbol	Gene name
AKT1	AKT serine/threonine kinase 1
IGF1	Insulin-like growth factor 1 (somatomedin C)
IL2	Interleukin 2
KIT	KIT proto-oncogene receptor tyrosine kinase
MALT1	Mucosa associated lymphoid tissue lymphoma translocation gene 1
NIK/MAP3K14^a	Mitogen-activated protein kinase kinase kinase 14
PIK3CA	Phosphoinositide-3-kinase, catalytic, alpha polypeptide
RELA^a	V-rel reticuloendotheliosis viral oncogene homolog A (avian)
SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1
TAK1/MAP3K7	Nuclear receptor subfamily 2 group C member 2
TLR4	Toll-like receptor 4
TNF/TNFα	Tumor necrosis factor (TNF superfamily, member 2)
TNFRSF10D/DcR2	Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TRAF6	TNF receptor-associated factor 6
TSP-1/THBS1	Thrombospondin 1

^aExperimentally validated target genes (Keklikoglou et al. [12]; Zhang et al. [10])

ISSN: 1423-0127