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Table 4 Effect of several drugs on uptake of [14C]L-citrulline in TR-BBB cells

From: Characteristics of L-citrulline transport through blood-brain barrier in the brain capillary endothelial cell line (TR-BBB cells)

Substrate

Concentration

(mM)

Uptake of [14C]L-citrulline

(% of control)

Control

 

100 ± 1.3

L-Dopa

0.5

52.1 ± 6.6**

2

21.6 ± 2.8***

Gabapentin

0.5

45.0 ± 2.52***

 

5

29.6 ± 2.73***

Verapamil

0.5

30.9 ± 0.3***

Qunidine

0.5

52.5 ± 3.0***

Dopamine

2

110.5 ± 2.7

Donepezil

2

85.5 ± 5.9

Riluzole

2

93.9 ± 8.3

Taurine

2

90.5 ± 4.4

  1. [14C]L-Citrulline uptake by TR-BBB cells was performed at pH7.4 and 37 °C for 5 min in the presence or absence (control) of 2 mM drugs (except for 500 μM quinidine, verapamil and 200 μM of riluzole). Each value represents the mean ± S.E.M. (n = 3–4). **p < 0.01, ***p < 0.001; significantly different from control
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Journal of Biomedical Science

ISSN: 1423-0127