Fig. 4

ALDH2*2 knock-in mice show higher levels of ROS with cisplatin treatment in the kidney cell lysates. ALDH2*2 knock-in mice were treated with cisplatin, euthanized in two days and tissues were collected. Cell homogenates were spun to isolate lysates, which include mitochondrial fraction (Figure 4) and ROS level was measured. Results represent mean ± SEMs (*p < 0.05 vs. PBS HET control (t-test))