Fig. 7
From: The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis
A hypothetical model of Lu/BCAM-laminin-mediated F-actin rearrangement, cell adhesion, migration and tumor formation during bladder tumorigenesis. Under Lu/BCAM overexpression conditions in the presence of laminin, the Erk/MAPK signaling pathway is activated, which is responsible for activation of RhoA and suppression of Rac-1. Subsequently, F-actin rearrangement and cell adhesion are induced, and cell migration was suppressed