Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Table 2 Significant variations between mutant and wild-type mice in the modified SHIRPA and grip strength analysis of line Kctd1 ^I27N

Test	Parameter	Heterozygous mutant males	Wild-type males	Heterozygous mutant females	Wild-type females	Genotype: P-value
Modified SHIRPA	Presence of tremor	6 of 15	0 of 15	0 of 15	0 of 15	0.02
	Presence of tail dragging	12 of 15	4 of 15	6 of 15	2 of 15	0.003
	Presence of trunk curl	2 of 15	0 of 15	8 of 15	2 of 15	0.02
Grip strength	Four paws (g)	219 ± 9	260 ± 20	223 ± 18	236 ± 22	< 0.001

9-week-old mice were tested. Number per genotype and sex: n = 15. Data are presented as total numbers (modified SHIRPA) and mean ± standard deviation (grip strength). Significance vs. wild-type controls: Exact P values are indicated for P < 0.05 (Modified SHIRPA: Fisher’s exact test)

ISSN: 1423-0127