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Table 2 Significant variations between mutant and wild-type mice in the modified SHIRPA and grip strength analysis of line Kctd1 I27N

From: Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Test Parameter Heterozygous mutant males Wild-type males Heterozygous mutant females Wild-type females Genotype:
P-value
Modified SHIRPA Presence of tremor 6 of 15 0 of 15 0 of 15 0 of 15 0.02
  Presence of tail dragging 12 of 15 4 of 15 6 of 15 2 of 15 0.003
  Presence of trunk curl 2 of 15 0 of 15 8 of 15 2 of 15 0.02
Grip strength Four paws (g) 219 ± 9 260 ± 20 223 ± 18 236 ± 22 < 0.001
  1. 9-week-old mice were tested. Number per genotype and sex: n = 15. Data are presented as total numbers (modified SHIRPA) and mean ± standard deviation (grip strength). Significance vs. wild-type controls: Exact P values are indicated for P < 0.05 (Modified SHIRPA: Fisher’s exact test)