Fig. 1

General condition and systemic parameters. Mice were treated either with LPS, PCI, CLP, or were left untreated (control). 0 h (control), 2 h, 4 h, 6 h, 12 h, 24 h, 48 h and 72 h after inflammation onset, the Clinical Severity Score (a) was assessed and the mice were sacrificed. Blood glucose content was determined from whole blood (b) and serum was obtained for TNF-α, IFN-γ, IL-6, IL-10, CXCL12 and ALAT measurements (c-h). Data are given as mean ± standard deviation (SD) or as median with interquartile ranges (CSS), respectively; n = 4–6 for each group and time point. Statistical significance was determined by using the non-parametric Kruskal-Wallis test, followed by pairwise Mann-Whitney U tests. Statistical comparisons were made versus the control of each group and are denoted as follows: LPS (asterisk, *), PCI (plus, +), CLP (diamond, #). A p value <0.05 (*,+,#) was considered statistically significant; a p value <0.01 (**,++,##) and a p value <0.001 (***,+++,###) are further specified