Fig. 1

TRIM28 multi-domain protein contributes to the regulation of a variety of intracellular processes. Core biological functions of TRIM28 including inhibition and degradation of p53 tumor suppressor, regulation of retrotransposition, regulation of gene expression through heterochromatization, mediation of DNA damage response, stimulation of EMT, maintenance of stem cell pluripotency and stimulation of autophagophore formation (induction of autophagy) are frequently intercepted by cancer cells to promote the proliferation and acquire resistance to stress inducing agents