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Table 1 The cancer-associated TRIM28 targets or interacting proteins

From: The complexity of TRIM28 contribution to cancer

Target or interacting protein Modification Effect Outcome Oncogenic or tumor suppressive Ref.
p53 deacetylation/ poly-ubiquitination inactivation/degradation of p53 suppression of p53-mediated apoptosis and promotion of tumor cell survival oncogenic [77, 85]
AMPK poly-ubiquitination degradation of AMPK amplification of mTORC signaling, downregulation of autophagy oncogenic [105, 106]
FBP1 poly-ubiquitination degradation of FBP1 stimulation of the Warburg effect and cancer progression oncogenic [110]
VPS34 (PI3KC3) SUMOylation activation of VPS34 induction of phagophore formation oncogenic [104]
E2F1 HDAC1-mediated deacetylation inactivation of E2F1 suppression of E2F1-mediated apoptosis after DNA damage in p53-null cells oncogenic [57, 60]
E2F3, E2F4 HDAC1-mediated deacetylation inactivation of E2F3, E2F4 repression of members of the E2F family that are critical for cell proliferation tumor suppressive [5]
MAGE-C2 none interaction with MAGE-C2 increases co-precipitation of TRIM28 with ATM upon genotoxic stress enhanced repair of damaged DNA oncogenic [53]
CBF-A/FTS-1 none interaction with CBF-A/FTS-1 induces the expression of VIM, FSP1 and other mesenchymal markers and represses the expression of epithelial markers (CDH1, ZO-1, etc.) activation of EMT proteome oncogenic [71]
TWIST1 none interaction and stabilization of TWIST1 promoting invasion and cell migration oncogenic [26]
URI-PP2A none de-phosphorylation of TRIM28 (at Ser824), chromatin condensation repression of L1 retroelement tumor suppressive [125]
  1. TRIM28 interaction with KRAB-ZNFs was omitted in this summary due to diverse and context-dependent role of these transcription factors [130]