Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

Neji, Sourour; Hadrich, Ines; Trabelsi, Houaida; Abbes, Salma; Cheikhrouhou, Fatma; Sellami, Hayet; Makni, Fattouma; Ayadi, Ali

doi:10.1186/s12929-017-0376-2

Journal of Biomedical Science

Table 3 Distribution of enzymatic activities from C. parapsilosis complex species isolated from different clinical sites

From: Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

	Phospholipase activity Mean (Pz) ± SD			Caseinase activity Mean (Pz) ± SD			Gelatinase activity Mean (Pz) ± SD			Hemolysin activity Mean (Pz) ± SD
	C.parapsilosis (n/N)	C.metapsilosis (n/N)	C.orthopsilosis (n/N)	C.parapsilosis (n/N)	C.metapsilosis (n/N)	C.orthopsilosis (n/N)	C.parapsilosis (n/N)	C.metapsilosis (n/N)	C.orthopsilosis (n/N)	C.parapsilosis (n/N)	C.metapsilosis (n/N)	C.orthopsilosis (n/N)
Blood (N = 64)	0.82 ± 0.12 (46/62)	1 (0/1)	1 (0/1)	0.46 ± 0.13 (60/62)	0.71 (1/1)	0.49 (1/1)	0.7 ± 0.07 (61/62)	0.65 (1/1)	0.65 (1/1)	0.6 ± 0.09 (62/62)	0.87 (1/1)	0.73 (1/1)
Urine (N = 31)	0.89 ± 0.12 (16/29)	1 (0/1)	1 (0/1)	0.52 ± 0.21 (25/29)	0.67 (1/1)	0.46 (1/1)	0.71 ± 0.11 (27/29)	0.8 (1/1)	0.73 (1/1)	0.62 ± 0.1 (29/29)	0.86 (1/1)	0.65 (1/1)
Auricular sample (N = 43)	0.88 ± 0.12 (22/39)	1 ± 0 (0/3)	1 (0/1)	0.59 ± 0.22 (31/39)	0.73 ± 0.15 (3/3)	0.59 (1/1)	0.71 ± 0.08 (38/39)	0.74 ± 0.14 (3/3)	0.75 (1/1)	0.62 ± 0.08 (39/39)	0.75 ± 0.09 (3/3)	0.51 (1/1)
Respiratory tract (N = 4)	0.88 ± 0.15 (2/4)	0 (0)	0 (0)	0.45 ± 0.05 (4/4)	0 (0)	0 (0)	0.67 ± 0.04 (4/4)	0 (0)	0 (0)	0.62 ± 0.08 (4/4)	0 (0)	0 (0)
Catheter (N = 9)	0.88 ± 0.12 (5/9)	0 (0)	0 (0)	0.39 ± 0.03 (9/9)	0 (0)	0 (0)	0.68 ± 0.02 (9/9)	0 (0)	0 (0)	0.61 ± 0.1 (9/9)	0 (0)	0 (0)
Skin (N = 8)	0.82 ± 0.14 (5/7)	1 (0/1)	0 (0)	0.38 ± 0.04 (7/7)	0.72 (1/1)	0 (0)	0.71 ± 0.14 (6/7)	0.67 (1/1)	0 (0)	0.6 ± 0.11 (7/7)	0.84 (1/1)	0 (0)
Nails (N = 2)	1 ± 0 (0/2)	0 (0)	0 (0)	0.44 ± 0.02 (2/2)	0 (0)	0 (0)	0.78 ± 0.01 (2/2)	0 (0)	0 (0)	0.5 ± 0.01 (2/2)	0 (0)	0 (0)
Oral cavity (N = 3)	0.84 ± 0.07 (3/3)	0 (0)	0 (0)	0.49 ± 0.13 (3/3)	0 (0)	0 (0)	0.7 ± 0.03 (3/3)	0 (0)	0 (0)	0.57 ± 0.07 (3/3)	0 (0)	0 (0)
Vagina (N = 1)	0.89 (1/1)	0 (0)	0 (0)	0.35 (1/1)	0 (0)	0 (0)	0.67 (1/1)	0 (0)	0 (0)	0.64 (1/1)	0 (0)	0 (0)
Peritoneal fluid (N = 1)	0.74 (1/1)	0 (0)	0 (0)	0.47 (1/1)	0 (0)	0 (0)	0.8 (1/1)	0 (0)	0 (0)	0.57 (1/1)	0 (0)	0 (0)
Hand carriage (N = 16)	0.82 ± 0.13 (10/15)	0 (0)	1 (0/1)	0.56 ± 0.2 (14/15)	0 (0)	0.44 (1/1)	0.76 ± 0.09 (14/15)	0 (0)	0.71 (1/1)	0.65 ± 0.11 (15/15)	0 (0)	0.63 (1/1)

N: number of tested isolates
n: number of isolates with positive activity for the corresponding hydrolytic enzyme
SD: standard deviation

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