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Table 5 In vitro susceptibility of C. parapsilosis complex species to eight antifungal drugs

From: Virulence factors, antifungal susceptibility and molecular mechanisms of azole resistance among Candida parapsilosis complex isolates recovered from clinical specimens

  C. parapsilosis (N = 55) C. metapsilosis (N = 6) C. orthopsilosis (N = 4)
  Range
μg/ml
Mean
μg/ml
S % SDD % R % Range
μg/ml
Mean
μg/ml
S % SDD % R % Range
μg/ml
Mean
μg/m
S % SDD % R %
Fluconazole 0.25–32 2.427 83.64 10.91 5.45 0.5–1 0.833 100 0 0 0.25–0.5 0.437 100 0 0
Itraconazole 0.008–0.5 0.096 83.64 16.36 0 0.016–0.125 0.078 100 0 0 0.016–0.064 0.052 100 0 0
Ketoconazole 0.008–16 0.321 ND ND ND 0.008–0.016 0.013 ND ND ND 0.008–0.016 0.010 ND ND ND
Posaconazole 0.008–1 0.106 ND ND ND 0.016–0.08 0.040 ND ND ND 0.032–0.08 0.052 ND ND ND
Voriconazole 0.008–8 0.190 90.91 7.27 1.82 0.008–0.032 0.018 100 0 0 0.008–0.016 0.010 100 0 0
Caspofungin 0.032–1.5 0.426 100 0 0 0.064–0.25 0.136 100 0 0 0.064–0.25 0.126 100 0 0
Amphotericin B 0.016–1 0.293 100 0 0 0.064–0.5 0.240 100 0 0 0.064–0.25 0.172 100 0 0
5-Flucytosine 0.03–2 0.110 100 0 0 0.03–0.03 0.030 100 0 0 0.03–0.064 0.055 100 0 0
  1. ND Not determined due to lack of validated clinical breakpoints, S susceptible, SDD dose-dependent susceptible, R resistant