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Table 1 The differences between Treg-of-B cells and the well-known Treg cells, including Foxp3+ Treg, Th3, and Tr1 cells

From: Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells

Treg cells Biomarkers Effector molecules Transcription factors Assisted cell types
Treg-of-B CD4+CD25+Foxp3-LAG3+ICOS+PD1+GITR+OX40+ Majorly contact-dependent
IL-10, LAG3, and CTLA4 has reported in reference
Undefined B cells
Foxp3+ Treg CD4+Foxp3+
Helios has reported in reference
IL-10, TGF-β, IL-35, LAP, CD39/CD73, cAMP, CTLA4, LAG3, IL-2/IL-7 consumption, granzyme B, galectin-1, DR5…etc Foxp3 DCs, macrophages, B cells
Th3 CD4+Foxp3-LAP+ Majorly TGF-β
IL-10 has reported in reference
Undefined DCs
Tr1 CD4+Foxp3-CD49b+LAG3+ CD226+ Majorly IL-10
TGF-β, CTLA4, and CD226 has reported in reference
Undefined
c-Maf, AhR has reported in reference
DCs, macrophages, B cells, mast cells…etc