Table 1 The differences between Treg-of-B cells and the well-known Treg cells, including Foxp3+ Treg, Th3, and Tr1 cells
From: Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells
Treg cells | Biomarkers | Effector molecules | Transcription factors | Assisted cell types |
|---|---|---|---|---|
Treg-of-B | CD4+CD25+Foxp3-LAG3+ICOS+PD1+GITR+OX40+ | Majorly contact-dependent IL-10, LAG3, and CTLA4 has reported in reference | Undefined | B cells |
Foxp3+ Treg | CD4+Foxp3+ Helios has reported in reference | IL-10, TGF-β, IL-35, LAP, CD39/CD73, cAMP, CTLA4, LAG3, IL-2/IL-7 consumption, granzyme B, galectin-1, DR5…etc | Foxp3 | DCs, macrophages, B cells |
Th3 | CD4+Foxp3-LAP+ | Majorly TGF-β IL-10 has reported in reference | Undefined | DCs |
Tr1 | CD4+Foxp3-CD49b+LAG3+ CD226+ | Majorly IL-10 TGF-β, CTLA4, and CD226 has reported in reference | Undefined c-Maf, AhR has reported in reference | DCs, macrophages, B cells, mast cells…etc |