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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters

Fig. 7

The expression ratio of the A allele and G allele in patients with heterozygous H558R. The expression levels of G allele and A allele was similar in genome DNA but the A allele (wild) expression was 1.38 fold higher than G allele (pathogenic) expression in mRNA. Allelic imbalance existed in mRNA in patients with heterozygous H558R. (P = 0.004 vs. genome DNA)

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Journal of Biomedical Science

ISSN: 1423-0127