Table 1 IC50 of CB533 and derivatives obtained from A375 cells. See Fig. 1 for chemical structures
Compound | IC50 (nM) |
|---|---|
CB533 | 390 |
1,4-NQ | > 10,000 |
Plumbagin | > 10,000 |
2 | 1500 |
3 | > 10,000 |
4 | > 10,000 |
5 | 3200 |
8 | 55 |
Pyr-1 | 10 |
Pyr-OH | 270 |
Pyr-1-hemisuccinate | > > 500 |