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Table 1 IC50 of CB533 and derivatives obtained from A375 cells. See Fig. 1 for chemical structures

From: Discovery and cellular stress pathway analysis of 1,4-naphthoquinone derivatives with novel, highly potent broad-spectrum anticancer activity

Compound IC50 (nM)
CB533 390
1,4-NQ > 10,000
Plumbagin > 10,000
2 1500
3 > 10,000
4 > 10,000
5 3200
8 55
Pyr-1 10
Pyr-OH 270
Pyr-1-hemisuccinate > > 500