Fig. 3
From: 99mTc-HYNIC-(tricine/EDDA)-FROP peptide for MCF-7 breast tumor targeting and imaging
a The ability binding of 99mTc- HYNIC-(tricine/EDDA)-FROP peptide on MCF-7 cells and comparison of this binding with binding to the SKOV-3 (ovarian cancer), A-549 (non-small cell lung cancer), T47D (breast cancer) and PC-3 (prostate cancer) cell lines and b HFFF2 (normal human fibroblast) cell line. The data are shown as the means ± SD. Data indicates significant difference (p values< 0.0001) in uptake of radiolabeled peptide between different cancer and normal cell lines. c In vitro specific binding of 99mTc-HYNIC-(tricine/EDDA)-FROP to MCF-7 cells. Pre-saturation was done by blocking unlabeled FROP (500-fold excess) peptide after 0.5 h incubation at 37 °C