99mTc-HYNIC-(tricine/EDDA)-FROP peptide for MCF-7 breast tumor targeting and imaging

Table 1 In Vitro Stability of ^99mTc-HYNIC-(tricine/EDDA)-FROP in succinate buffer and normal saline at room temperature (n = 3)

%RCP^a	%RCP in succinate buffer (peptide reaction mixture)				%RCP in normal saline				Log p^b
^99mTc-FROP	2 h	4 h	6 h	24 h	2 h	4 h	6 h	24 h	−2.03 ± 0.03
^99mTc-FROP	99.6 ± 0.2	99.5 ± 0.4	99.1 ± 0.9	96.8 ± 2.4	99.5 ± 0.4	99.1 ± 0.9	99 ± 0.8	94.6 ± 2.7	−2.03 ± 0.03

^aRCP = Radiochemical purity that was determined with TLC method, ^bPartition coefficient between n-octanol and PBS

ISSN: 1423-0127