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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes

Fig. 5

Specific T-cell response in spleen. BALB/c mice (n = 5/group) were immunized s.c. with 10 μg of Flg-HA2–2-4M2ehs or FlgSh-HA2–2-4M2ehs on days 0, 14, 28. Splenocytes were isolated from 5 mice of each group at day 14 post-second boost and assayed for M2e-specific and A/H3N2-specific CD4+ and CD8+ T-cell responses. a Antigen-specific CD4+ and CD8+ T-cells. b Antigen-specific Tem and Tcm cells. Data are presented as the mean ± SEM. Statistical significance was determined using the Mann-Whitney U-test. The P values between groups are indicated. *significant difference from control group, p < 0.02

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Journal of Biomedical Science

ISSN: 1423-0127