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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes

Fig. 7

Detection of viral titers in mouse lung. Mice (n = 5/group) immunized with fusion proteins Flg-HA2–2-4M2ehs and FlgSh-HA2–2-4M2ehs were i.n. challenged with: A/Shanghai/2/2013(H7N9)-PR8-IDCDC (10LD50); A/Aichi/2/68(H3N2) (10LD50); A/California/07/09H1N1pdm09 (100MID); or А/Chicken/Kurgan/05/05RG(H5N1) (100MID). Viral titers were detected 6 days post challenge. The data are expressed as log TCID50. Horizontal bars indicate mean among 5 mice per group. The lower limit of detection is 0.5log TCID50. Statistical significance was determined using the Mann-Whitney U-test. The P values between immunized and control group are indicated

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Journal of Biomedical Science

ISSN: 1423-0127