Skip to main content

Table 2 Effects of ASICs knockout on neural activity of mechanoreceptors

From: Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

 

ASIC1 KO

ASIC2 KO

ASIC3 KO

ASIC2/3

ASIC1/2/3

Nodose arterial baroreceptor

 

⇎ [34]

   

Gastroesophageal mechanoreceptor

Tension receptor ↑ [17, 127] Mucosal receptor ↑ [30]

Tension receptor ↓ [30] Mucosal receptor ↑ [30]

Tension receptor ↓ [30]

  

Colonic mechanoreceptor

Mesentric afferent ↑ [30] Serosal afferent ↑ [30]

Mesentric afferent⇋ [30] Serosal afferent ↑ [30]

Mesentric afferent ↓ [30] Serosal afferent ↓ [30] Colonic nociceptor ↓ [70]

  

Cochlear mechanoreceptor

 

⇋ [55]

   

Muscle spindle mechanoreceptor

  

⇎ [40]

  

Cutaneous RA mechanoreceptor

 

↓ [30] ⇋ [55]

↑ [38]

 

⇋ [77]

Cutaneous SA mechanoreceptor

 

↓ [30]

⇋ [38]

 

⇋ [77]

Cutaneous A-fiber mechanonociceptor

  

↓ [38]

 

↑ [77]

Down-hair mechanoreceptor

  

⇋ [38]

 

⇋ [77]

Cutaneous afferent C-nociceptor

  

⇋ [38]

 

⇋ [77]

DRG-RA MA-current neurons

 

⇋ [114]

⇋ [114]

⇋ [114]

 

DRG-IA MA-current neurons

 

⇋ [114]

⇋ [114]

⇋ [114]

 

DRG-SA MA current neurons

 

⇋ [114]

⇋ [114]

⇋ [114]

 

DRG- Proprioceptor

  

Tether model ↓ [40] Bilayer model ⇋ [40]

  
  1. IA intermediately adapting, RA rapidly adapting, SA slowly adapting, MA mechanically activated
  2. ⇋, no change; ↑, increased activity; ↓, decreased activity; ⇎, impaired or disturbed mechanotransduction