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Table 2 Effects of ASICs knockout on neural activity of mechanoreceptors

From: Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

  ASIC1 KO ASIC2 KO ASIC3 KO ASIC2/3 ASIC1/2/3
Nodose arterial baroreceptor   [34]    
Gastroesophageal mechanoreceptor Tension receptor ↑ [17, 127] Mucosal receptor ↑ [30] Tension receptor ↓ [30] Mucosal receptor ↑ [30] Tension receptor ↓ [30]   
Colonic mechanoreceptor Mesentric afferent ↑ [30] Serosal afferent ↑ [30] Mesentric afferent [30] Serosal afferent ↑ [30] Mesentric afferent ↓ [30] Serosal afferent ↓ [30] Colonic nociceptor ↓ [70]   
Cochlear mechanoreceptor   [55]    
Muscle spindle mechanoreceptor    [40]   
Cutaneous RA mechanoreceptor   ↓ [30] [55] ↑ [38]   [77]
Cutaneous SA mechanoreceptor   ↓ [30] [38]   [77]
Cutaneous A-fiber mechanonociceptor    ↓ [38]   ↑ [77]
Down-hair mechanoreceptor    [38]   [77]
Cutaneous afferent C-nociceptor    [38]   [77]
DRG-RA MA-current neurons   [114] [114] [114]  
DRG-IA MA-current neurons   [114] [114] [114]  
DRG-SA MA current neurons   [114] [114] [114]  
DRG- Proprioceptor    Tether model ↓ [40] Bilayer model [40]   
  1. IA intermediately adapting, RA rapidly adapting, SA slowly adapting, MA mechanically activated
  2. , no change; ↑, increased activity; ↓, decreased activity; , impaired or disturbed mechanotransduction