Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

Table 2 Effects of ASICs knockout on neural activity of mechanoreceptors

	ASIC1 KO	ASIC2 KO	ASIC3 KO	ASIC2/3	ASIC1/2/3
Nodose arterial baroreceptor		⇎ [34]
Gastroesophageal mechanoreceptor	Tension receptor ↑ [17, 127] Mucosal receptor ↑ [30]	Tension receptor ↓ [30] Mucosal receptor ↑ [30]	Tension receptor ↓ [30]
Colonic mechanoreceptor	Mesentric afferent ↑ [30] Serosal afferent ↑ [30]	Mesentric afferent⇋ [30] Serosal afferent ↑ [30]	Mesentric afferent ↓ [30] Serosal afferent ↓ [30] Colonic nociceptor ↓ [70]
Cochlear mechanoreceptor		⇋ [55]
Muscle spindle mechanoreceptor			⇎ [40]
Cutaneous RA mechanoreceptor		↓ [30] ⇋ [55]	↑ [38]		⇋ [77]
Cutaneous SA mechanoreceptor		↓ [30]	⇋ [38]		⇋ [77]
Cutaneous A-fiber mechanonociceptor			↓ [38]		↑ [77]
Down-hair mechanoreceptor			⇋ [38]		⇋ [77]
Cutaneous afferent C-nociceptor			⇋ [38]		⇋ [77]
DRG-RA MA-current neurons		⇋ [114]	⇋ [114]	⇋ [114]
DRG-IA MA-current neurons		⇋ [114]	⇋ [114]	⇋ [114]
DRG-SA MA current neurons		⇋ [114]	⇋ [114]	⇋ [114]
DRG- Proprioceptor			Tether model ↓ [40] Bilayer model ⇋ [40]

IA intermediately adapting, RA rapidly adapting, SA slowly adapting, MA mechanically activated
⇋, no change; ↑, increased activity; ↓, decreased activity; ⇎, impaired or disturbed mechanotransduction

ISSN: 1423-0127