Prognostic value of localization of epidermal growth factor receptor in lung adenocarcinoma

Table 1 Characteristics of high membranous and nuclear EGFR expression in lung adenocarcinoma

Characteristics	No	High membranous EGFR (N = 69)	OR (95% CI)	P value	High nuclear EGFR (N = 63)	OR (95% CI)	P value
Age (median = 71 yr)				0.423			0.966
Younger	77	30 (39.0)^a	1		30 (38.9)	1
Older > 70 yr	84	39 (46.4)	1.36 (0.73~ 2.54)		33 (39.3)	1.01 (0.54~ 1.91)
Gender				0.436			0.692
Female	90	41 (45.6)	1		34 (37.8)	1
Male	71	28 (39.5)	0.78 (0.41~ 1.46)		29 (40.8)	1.14 (0.60~ 1.46)
Smoking				0.776			0.919
Never	103	58 (56.3)	1		40 (38.8)	1
Current or past	58	34 (58.6)	0.91 (0.47~ 1.75)		23 (39.7)	1.04 (0.54~ 1.20)
Tumor stage (2 missing)				0.584			0.455
T1/T2	80	33 (41,3)	1		34 (42.5)	1
T3/T4	79	36 (45.6)	1.19 (0.64~ 2.23)		29 (36.7)	0.78 (0.42~ 1.48)
Nodal stage (1 missing)				0.031			0.466
L0/L1	68	36 (52.9)	2.01 (1.06~ 3.81)^b		29 (42.6)	1.27 (0.67~ 2.41)
L2/L3	92	33 (35.9)	1		34 (36.9)	1
Metastasis				0.090			0.118
without	67	34 (50.7)	1		31 (46.3)	1
with	94	35 (37.2)	0.58 (0.30~ 1.09)		32 (34.0)	0.60 (0.32~ 1.14)
TNM stage				0.045			0.247
Localized (stage I/II)	43	24 (55.8)	2.05 (1.01~ 4.16)^c		20 (46.5)	1.52 (0.75~ 3.08)
Distant (stage III/IV)	118	45 (38.1)	1		43 (36.4)	1
Brain metastasis				0.515			0.890
without	114	47 (41.2)	1		45 (39.5)	1
with	47	22 (46.8)	1.25 (0.63~ 2.49)		18 (38.3)	0.95 (0.47~ 1.91)
EGFR mutations^d				0.205			0.634
Wildtype	74	28 (37.8)	1		27 (36.5)	1
Mutations^e	77	37 (48.0)	1.52 (0.79~ 2.91)		31 (40.3)	1.17 (0.61~ 2.26)

Chi-squared test
^aData are presented as n (%) of row
^bAdjusted OR (95% CI) = 3.92 (1.25~ 12.27), p = 0.019
^cAdjusted OR (95% CI) = 1.37 (0.32~ 5.98) p = 0.674
^d10 missing
^eIncluding 3 in exon 18, 37 in exon 19, 3 in exon 20, 33 in exon 21and 1 in exon 19/20
Note: Boldfaces as statistical significance

ISSN: 1423-0127