Fig. 1

Structure of the functional domain of the LRRK2 protein and the pathogenic mutations associated with PD. ARM, armadillo; ANK, ankyrin repeat; LRR, leucine-rich repeat; ROC, Ras of complex proteins: GTPase; COR, C-terminal of ROC; WD40, WD-40 domain. Potential pathogenic mutations are shown in red, and risk polymorphisms in Asian populations are shown in blue