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Table 3 Upregulated genes associated with EGF, FGF, and insulin pathways in HCT116-derived tumorspheres (analyzed using PANTHER, http://pantherdb.org/)

From: STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening

Pathway Gene fold chang (log2) qvalue
EGF RRAS 1.9498 6.33E-25
RAC2 1.1094 4.70E-07
PIK3CD 1.2025 0.002031
STAT2 1.1837 7.66E-06
MAPK15 1.2498 5.45E-07
PRKCG 2.2982 0.0042873
SHC2 2.6131 0.0019177
STAT3 1.0825 1.18E-11
PPP2R5B 2.4064 1.95E-14
SFN 1.2086 2.92E-57
AREG 1.6495 2.22E-52
FGF FGFR1 1.0804 3.25E-10
RAC2 1.1094 4.70E-07
PIK3CD 1.2025 0.002031
PRKCG 2.2982 0.0042873
PPP2R5B 2.4064 1.95E-14
SFN 1.2086 2.92E-57
Insulin IRS2 2.0046 1.06E-07
FOXO3 1.3511 9.38E-12
PDK1 1.4964 0.00013109
PIK3CD 1.2025 0.002031