Table 3 Upregulated genes associated with EGF, FGF, and insulin pathways in HCT116-derived tumorspheres (analyzed using PANTHER, http://pantherdb.org/)
Pathway | Gene | fold chang (log2) | qvalue |
|---|---|---|---|
EGF | RRAS | 1.9498 | 6.33E-25 |
RAC2 | 1.1094 | 4.70E-07 | |
PIK3CD | 1.2025 | 0.002031 | |
STAT2 | 1.1837 | 7.66E-06 | |
MAPK15 | 1.2498 | 5.45E-07 | |
PRKCG | 2.2982 | 0.0042873 | |
SHC2 | 2.6131 | 0.0019177 | |
STAT3 | 1.0825 | 1.18E-11 | |
PPP2R5B | 2.4064 | 1.95E-14 | |
SFN | 1.2086 | 2.92E-57 | |
AREG | 1.6495 | 2.22E-52 | |
FGF | FGFR1 | 1.0804 | 3.25E-10 |
RAC2 | 1.1094 | 4.70E-07 | |
PIK3CD | 1.2025 | 0.002031 | |
PRKCG | 2.2982 | 0.0042873 | |
PPP2R5B | 2.4064 | 1.95E-14 | |
SFN | 1.2086 | 2.92E-57 | |
Insulin | IRS2 | 2.0046 | 1.06E-07 |
FOXO3 | 1.3511 | 9.38E-12 | |
PDK1 | 1.4964 | 0.00013109 | |
PIK3CD | 1.2025 | 0.002031 |