Skip to main content

Advertisement

Table 1 The 3 categories of H. pylori virulence factors and their functions

From: The impacts of H. pylori virulence factors on the development of gastroduodenal diseases

The three categories of virulence factors Biological functions or associated diseases
Colonization Biological functions
Urease  Neutralize gastric acid
Flagella Chemotaxis system  Bacterial movement to epithelial surface & deep gland
Adhesins  Adherence to gastric epithelial cells
 • BabA  
 • SabA  
 • Lewis antigens  
 • OipA  
Immune escape Biological functions
 LPS & Flagella  Low immunogenicity
 Molecular mimicry
 Induce anti-inflammatory response
 CagA & T4SS  Suppress phagocytosis
 Decrease antimicrobial peptide
 Induce tolerogenic dendritic cell
 Block effector T cell response
 VacA  Suppress phagocytosis
 Induce tolerogenic dendritic cell
 Block effector T cell response
 Gamma-glutamyl transpeptidase  Induce tolerogenic dendritic cell
 Block effector T cell response
 Cholesterol-α-glucosyltransferase  Suppress phagocytosis
 Catalase Superoxide dismutase  Suppress and ROS & NO
 Arginase  Suppress ROS & NO
 Block effector T cell response
Disease induction Associated diseases
 CagA & T4SS  Gastric adenocarcinoma, MALToma & PUD
 VacA  Gastric adenocarcinoma & PUD
 BabA  Gastric adenocarcinoma & PUD
 HtrA  Gastric adenocarcinoma
 DupA  Duodenal ulcer
 IceA  PUD
 OipA  PUD
  1. LPS Lipopolysaccharide, T4SS type IV secretion system, ROS reactive oxygen species, NO nitric oxide, PUD peptic ulcer disease