From: The impacts of H. pylori virulence factors on the development of gastroduodenal diseases
The three categories of virulence factors | Biological functions or associated diseases |
---|---|
Colonization | Biological functions |
Urease | Neutralize gastric acid |
Flagella Chemotaxis system | Bacterial movement to epithelial surface & deep gland |
Adhesins | Adherence to gastric epithelial cells |
• BabA | |
• SabA | |
• Lewis antigens | |
• OipA | |
Immune escape | Biological functions |
LPS & Flagella |
Low immunogenicity Molecular mimicry Induce anti-inflammatory response |
CagA & T4SS |
Suppress phagocytosis Decrease antimicrobial peptide Induce tolerogenic dendritic cell Block effector T cell response |
VacA |
Suppress phagocytosis Induce tolerogenic dendritic cell Block effector T cell response |
Gamma-glutamyl transpeptidase |
Induce tolerogenic dendritic cell Block effector T cell response |
Cholesterol-α-glucosyltransferase | Suppress phagocytosis |
Catalase Superoxide dismutase | Suppress and ROS & NO |
Arginase |
Suppress ROS & NO Block effector T cell response |
Disease induction | Associated diseases |
CagA & T4SS | Gastric adenocarcinoma, MALToma & PUD |
VacA | Gastric adenocarcinoma & PUD |
BabA | Gastric adenocarcinoma & PUD |
HtrA | Gastric adenocarcinoma |
DupA | Duodenal ulcer |
IceA | PUD |
OipA | PUD |