|
c-Myc
|
K63-linked poly-ubiquitination
|
c-Myc transactivation
|
Increased cell proliferation
|
[43]
|
|
N-Myc
|
K48-linked poly-ubiquitination
|
Degradation
|
Dysregulated neural differentiation; Perturbed HSC self-renewal
|
[60,61,62]
|
|
Dvl
|
K63-linked poly-ubiquitination
|
Inhibit Dvl multimerization
|
Negative feedback loop to Wnt signaling
|
[63]
|
|
Atoh1
|
Poly-ubiquitination
|
Phosphorylation-dependent degradation
|
Increased neuronal differentiation
|
[71]
|
|
Mcl-1
|
Poly-ubiquitination
|
Degradation
|
Increased DNA-damage induced apoptosis; Increased hepatocyte apoptosis
|
[77]
|
|
p53
|
Poly-ubiquitination
|
Degradation
|
Reduced cell growth arrest; Increased anti-apoptosis
|
[87]
|
|
HDAC2
|
Poly-ubiquitination
|
Degradation
|
Apoptosis
|
[92]
|
|
Miz1; c-Myc/Miz1
|
K48-linked poly-ubiquitination
|
Degradation
|
JNK activation and apoptosis; Ras signaling suppression;
|
[30, 102]
|
|
Cdc6
|
Poly-ubiquitination
|
Degradation
|
Released from chromatin; Inhibition of preRC assembly
|
[103]
|
|
BRCA1
|
Poly-ubiquitination
|
Degradation
|
Reduced DNA repair
|
[116, 117]
|
|
Pol β
|
Mono-ubiquitination
|
Degradation
|
Decreased DNA repair
|
[39]
|
|
Pol λ
|
Mono-ubiquitination
|
Degradation
|
Decreased DNA repair; Reduced chromatin binding
|
[40]
|
|
HAUSP
|
K63-linked poly-ubiquitination
|
Enhanced HAUSP deubiquitase activity; enhanced transactivation
|
EMT, chromatin modification
|
[124]
|
|
TIAM1
|
Poly-ubiquitination
|
Degradation
|
Enhanced migration, invasion
|
[126]
|
|
MyoD
|
Poly-ubiquitination
|
Degradation
|
Myogenesis
|
[138]
|
|
H1.3
|
Poly-ubiquitination
|
Degradation
|
Ovarian epithelial cell transformation; Tumor growth
|
[139]
|
|
H2AX
|
Poly-ubiquitination
|
Degradation
|
Decreased DNA repair
|
[142]
|
