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Table 2 Pathways interacting with DISC1 and/or TRAX

From: The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions

Pathway

Binding partner

Full name

Interaction with TRAX

Interaction with DISC1

cAMP/PKA

A2AR [5, 132, 134]

A2A adenosine receptor

+ [132]

Nd

Akap9 [168]

A-Kinase Anchoring Protein 9

+ [168]

+ [194, 195]

ATF4

Activating Transcription Factor 4

nd

+ [194, 196, 197]

ATF5

Activating Transcription Factor 5

nd

+ [194, 198,199,200]

ATF7IP

Activating Transcription Factor 7

nd

+ [194]

D2R

Dopamine D2 receptor

nd

+ [146]

PDE4B

Phosphodiesterase 4B

nd

+ [8, 194, 201]

PDE4D

Phosphodiesterase 4D

nd

+ [194, 202]

Wnt signaling

GSK3β [5]

Glycogen Synthase Kinase 3 β

+ [5]

+ [5, 7, 194]

β-catenin

Catenin β-1

nd

+ [7, 194, 203]

DIXDC1

DIX Domain Containing 1

nd

+ [194, 204]

TNIK

TRAF2 And NCK Interacting Kinase

nd

+ [194, 205, 206]

WNT3A

Wnt Family Member 3A

nd

+ [194]

Intracellular Transport

Dynactin

Dynactin

nd

+ [207]

FEZ1

Fasciculation And Elongation Protein Zeta 1

nd

+ [208, 209]

HZF

Haematopoetic zinc finger

nd

+ [12]

KIF1B

Kinesin Family Member 1B

nd

+ [12]

KIF2A

Kinesin Family Member 2A

+ [134, 183]

nd

KIF5A

Kinesin Family Member 5A

nd

+ [11, 12]

Miro1/2

Mitochondrial Rho GTPase 1/2

nd

+ [9, 210]

SNPH

Syntaphilin

nd

+ [10]

TRAK1/2

Trafficking kinesin protein-1/2

nd

+ [9]

Translin

Tanslin

+ [211]

nd

DNA repair

ATM

ataxia-telangiectasia mutated

+ [137]

nd

C1D

nuclear matrix protein C1D

+ [136]

nd

Rad21

Double-strand-break repair protein rad21 homolog

Nd

+ [212, 213]

  1. Accumulating evidence suggests the involvement of DISC1/TRAX in several signaling pathways and machineries that mediate a wide variety of cellular functions. +, direct interaction. nd, not determined. The corresponding references are listed in parentheses