Fig. 2

Hepatocellular transporters, enzymes, and regulators involving in bile transport, metabolism, and secretion. A1AD, alpha-1 antitrypsin deficiency; A1AT, alpha-1 antitrypsin; ALG, Alagille syndrome; BAs, bile acids; BSEP, bile salt export pump; Canalicular, canalicular membrane; CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; DJ, Dubin-Johnson syndrome; FIC1, familial intrahepatic cholestasis 1; FXR, farnesoid X receptor; JAG1, jagged 1; MDR3, multidrug resistance protein 3; MRP2, multidrug resistance-associated protein 2; MRP3, multidrug resistance-associated protein 3; MRP4, multidrug resistance-associated protein 4; MYO5B, myosin VB; NTCP, sodium/taurocholate co-transporting polypeptide; OATP1B1, organic-anion-transporting polypeptide 1B1; OATP1B3, organic-anion-transporting polypeptide 1B3; OSTα/β, organic solute transporter-α/β; PC, phosphatidylcholine; PFIC, progressive familial intrahepatic cholestasis; PS, phosphatidylserine; Sinusoidal, sinusoidal membrane; SHP, small heterodimer partner; TJP2, tight junction protein 2