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Table 1 Methylation status of ZNF667-AS1 in LSCC tissues

From: Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma

Group N Methylation frequency
Region 1 Region 2 Region 3
   n (%) P n (%) P n (%) P
Age        
 <60 13 8 (61.5) 1.0 8 (61.5) 0.473 10 (76.9) 0.2673
  ≥ 60 19 12 (63.2)   8 (42.1)   10 (52.6)  
Smoking        
 Positive 27 18 (66.7) 0.338 14 (51.9) 1.0 18 (66.7) 0.338
 Negative 5 2 (40.0)   2 (0.4)   2 (40.0)  
Drinking        
 Positive 19 11 (57.9) 0.713 9 (47.4) 1.0 14 (73.7) 0.150
 Negative 13 9 (69.2   7 (53.8)   6 (46.2)  
Pathological differentiation        
 Well 15 9 (60.0) 1.0 4 (26.7) 0.032 7 (46.7) 0.144
 Moderate/poor 17 11 (64.7)   12 (70.6)   13 (76.5)  
TNM stage        
 I + II 14 11 (78.6) 0.147 8 (57.1) 0.722 10 (71.4) 0.471
 III + IV 18 9 (50.0)   8 (44.4)   10 (55.6)  
LN metastasis        
 Positive 12 7 (58.3) 0.734 7 (58.3) 0.716 7 (58.3) 0.724
 Negative 20 13 (65.0)   9 (45.0)   13 (65.0)  
Tissues        
 Tumor 32 20 (62.5) < 0.001 16 (50.0) < 0.001 20 (62.5) < 0.001
 Normal 32 3 (9.3)   1 (3.1)   4 (12.5)  
  1. In 32 tumor tissues, hypermethylation of ZNF667-AS1 was associated with moderate/poor pathological differentiation. Comparing the tumor tissues with normal tissues of LSCC, the rate of hypermethylation was significantly higher in tumor tissues in all of the three regions of CpG island