Fig. 9From: SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genesModel of SOX17 molecular functions in sensitization of chemoradiation. a Tumor suppressor SOX17 transcriptionally inactivates DNA repair and DNA damage responsive genes to enhance sensitivity to chemoradiation in ESCC. b Low SOX17 protein expression resulting from gene hypermethylation is associated with resistance to chemoradiation in ESCC. Low SOX17 immunoreactivity could be a biomarker for CCRT response prediction in pre-treatment endoscopic biopsies from ESCC patientsBack to article page