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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes

Fig. 9

Model of SOX17 molecular functions in sensitization of chemoradiation. a Tumor suppressor SOX17 transcriptionally inactivates DNA repair and DNA damage responsive genes to enhance sensitivity to chemoradiation in ESCC. b Low SOX17 protein expression resulting from gene hypermethylation is associated with resistance to chemoradiation in ESCC. Low SOX17 immunoreactivity could be a biomarker for CCRT response prediction in pre-treatment endoscopic biopsies from ESCC patients

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