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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder

Fig. 5

The OXTR mRNA levels and protein expressions in the mPFC, hippocampus, and amygdala. SPS reduced the OXT mRNA level in the mPFC, hippocampus, and amygdala, but only the mPFC OXTR mRNA level can be reversed by OXT administration (a-c). OXT reversed the SPS-decreased OXT protein expressions in the mPFC and amygdala, and these effects can be blocked by ASB (D, F). SPS and drugs (OXT and ASB) did not affect the hippocampus OXT protein expression (E). SPS = single prolonged stress, VEH = vehicle, OXT = oxytocin, ASB = atosiban, OXTR = oxytocin receptor. Bars represent mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, compared with Control-Veh; ##p < 0.01, ###p < 0.001, compared with Control-OXT; @p < 0.05, @@p < 0.01, @@@p < 0.001, compared with SPS-OXT. N = 5 for the mRNA levels (A-C); N = 4 for the protein expressions (d-f)

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