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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder

Fig. 6

The CRHR1 mRNA levels and protein expressions in the mPFC, hippocampus, and amygdala. OXT reversed the SPS-elevated the hippocampus CRHR1 mRNA level, but SPS and drugs (OXT and ASB) did not affect the CRHR1 mRNA level in mPFC and amygdala (a-c). SPS increased the CRHR1 protein expressions in the mPFC and amygdala, but only the mPFC CRHR1 protein expressions could reverse by OXT (d, f). SPS and drugs (OXT and ASB) did not affect the hippocampus CRHR1 protein expression (E). SPS = single prolonged stress, VEH = vehicle, OXT = oxytocin, ASB = atosiban, OXTR = oxytocin receptor. Bars represent mean ± SEM; *p < 0.05, **p < 0.01, compared with Control-Veh; ##p < 0.01, compared with Control-OXT; &&p < 0.01, compared with SPS-OXT. N = 5 for the mRNA levels (a-c); N = 4 for the protein expressions (d-f)

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Journal of Biomedical Science

ISSN: 1423-0127