Fig. 5
From: RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Schematic structure of oncoprotein E6. Protein structure and functions of HPV16 E6. Four zinc-binding motifs are indicated as grey boxes. The two zinc fingers are shown together with regions that are involved in interacting with some of its cellular target proteins. E6 contains PDZ domain–binding motif at its C-terminal extremity and three Nuclear localization signals (NLS). Functions associated with proteins in different regions are indicated by arrows