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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation

Fig. 8

TNF-α-induced FAK phosphorylation is decreased by pUR4. After being pretreated with 1000 nM scrambled peptide or 1000 nM pUR4 for 16 h, bEND.3 cells were stimulated with TNF-α (20 ng/mL) for 6 h. FAK phosphorylation at Tyr-397 (a) and Tyr-576 (c) were determined through immunoblotting. Quantitative analysis of phosphorylated FAK at Tyr-397 (b) and Tyr-576 (d) normalized to total FAK (n = 4). Data are represented as means ± standard deviations. *P < 0.05 and **P < 0.01, one-way ANOVA followed by Tukey’s multiple comparison test

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