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Table 1 Functional effects of EV cargos in cancers

From: Basics and applications of tumor-derived extracellular vesicles

EV cargo Type of cargo Functional effects Reference
Amino acids or TCA-cycle intermediates Metabolites Promote cancer growth [74]
Annexin A6 Protein Pre-mPremetastatic niche formation [31]
Integrins Protein Organotropic metastasis [39]
Lethal-7 miRNA family miRNA Maintain the highly metastatic tumorigenic phenotype [56]
MET Protein Pre-mPremetastatic niche formation [41]
miR-223 miRNA Enhance cancer invasion [57]
miR-10b and miR-21 miRNA Regulate cancer development [59]
Mitochondrial DNA   Regulate escape from dormancy in therapy-resistant cancers [47]
Mutant K-Ras Protein Enhance three-dimensional growth of cells [68]
TGF-β Protein Promote fibroblast-myofibroblast differentiation [64, 65]
Tissue factor Protein Regulate pro-coagulant activity of endothelial cells [66]